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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
RIPK2
All Species:
5.15
Human Site:
S401
Identified Species:
12.59
UniProt:
O43353
Number Species:
9
Phosphosite Substitution
Charge Score:
0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O43353
NP_003812.1
540
61195
S401
W
D
S
T
I
S
G
S
Q
R
A
A
F
C
D
Chimpanzee
Pan troglodytes
XP_519850
539
61066
Q401
D
S
T
I
S
G
S
Q
R
A
A
F
C
D
H
Rhesus Macaque
Macaca mulatta
XP_001084563
540
61225
S401
W
D
S
T
I
S
A
S
Q
R
A
A
F
C
D
Dog
Lupus familis
XP_535125
538
61029
K401
S
N
I
S
A
A
Q
K
W
T
F
C
D
H
K
Cat
Felis silvestris
Mouse
Mus musculus
P58801
539
60382
P401
D
G
I
V
S
V
P
P
G
A
A
F
C
D
R
Rat
Rattus norvegicus
Q9Z2P5
478
52215
G351
L
H
L
E
E
P
S
G
S
V
P
E
R
L
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511321
791
87316
E396
L
S
L
S
F
E
R
E
N
S
V
S
D
I
S
Chicken
Gallus gallus
NP_001026114
574
63953
A406
K
Q
S
I
K
K
C
A
D
G
D
S
G
G
L
Frog
Xenopus laevis
NP_001080415
720
79835
E395
G
S
L
S
L
S
F
E
K
D
C
S
V
L
D
Zebra Danio
Brachydanio rerio
NP_919392
584
65933
S411
K
P
L
M
D
N
C
S
P
N
N
L
S
P
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.2
97.4
86.6
N.A.
84.2
24.8
N.A.
25.6
63.4
25.9
49.3
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
99.4
97.7
90.7
N.A.
89.8
40.9
N.A.
39.7
74.2
44.3
64.7
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
6.6
93.3
0
N.A.
6.6
0
N.A.
0
6.6
13.3
6.6
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
20
93.3
20
N.A.
6.6
0
N.A.
13.3
20
40
20
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
10
10
10
10
0
20
40
20
0
0
0
% A
% Cys:
0
0
0
0
0
0
20
0
0
0
10
10
20
20
0
% C
% Asp:
20
20
0
0
10
0
0
0
10
10
10
0
20
20
30
% D
% Glu:
0
0
0
10
10
10
0
20
0
0
0
10
0
0
10
% E
% Phe:
0
0
0
0
10
0
10
0
0
0
10
20
20
0
0
% F
% Gly:
10
10
0
0
0
10
10
10
10
10
0
0
10
10
0
% G
% His:
0
10
0
0
0
0
0
0
0
0
0
0
0
10
10
% H
% Ile:
0
0
20
20
20
0
0
0
0
0
0
0
0
10
0
% I
% Lys:
20
0
0
0
10
10
0
10
10
0
0
0
0
0
10
% K
% Leu:
20
0
40
0
10
0
0
0
0
0
0
10
0
20
10
% L
% Met:
0
0
0
10
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
10
0
0
0
10
0
0
10
10
10
0
0
0
0
% N
% Pro:
0
10
0
0
0
10
10
10
10
0
10
0
0
10
0
% P
% Gln:
0
10
0
0
0
0
10
10
20
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
10
0
10
20
0
0
10
0
10
% R
% Ser:
10
30
30
30
20
30
20
30
10
10
0
30
10
0
10
% S
% Thr:
0
0
10
20
0
0
0
0
0
10
0
0
0
0
10
% T
% Val:
0
0
0
10
0
10
0
0
0
10
10
0
10
0
0
% V
% Trp:
20
0
0
0
0
0
0
0
10
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _